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The Nobel Prize in Chemistry 2015 awards three pioneering scientists who have mapped how several of these repair systems function at a detailed molecular level. Investigator at Howard Hughes Medical Institute and James B.
Their work has provided fundamental knowledge of how a living cell functions and is, for instance, used for the development of new cancer treatments. Sarah Graham Kenan Professor of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.In its wild-type (normal) form, it contains 6-35 glutamine residues.However, in individuals affected by Huntington's disease (an autosomal dominant genetic disorder), it contains more than 36 glutamine residues (highest reported repeat length is about 250).The 5' end of the HD gene has a sequence of three DNA bases, cytosine-adenine-guanine (CAG), coding for the amino acid glutamine, that is repeated multiple times. Normal persons have a CAG repeat count of between seven and 35 repeats.Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co.